Weibin Wang, Ph.D.

Assistant Professor

Doctoral Advisor

Contact information

E-mail: weibinwang@bjmu.edu.cn

Education and research experience

(1) 2004-2008: B.S., Capital Medical University (Beijing, China), Department of Medical Experiment

(2) 2008-2011: M.S., Peking University Health Science Center (Beijing, China), Department of Biochemistry and Molecular Biology

(3) 2011-2014: Ph.D., Peking University Health Science Center (Beijing, China), Department of Biochemistry and Molecular Biology

(4) 2014-2019: Postdoc, Yale University (New Haven, USA), Department of Molecular Biophysics and Biochemistry

(5) 2019-Present: Assistant Professor, Peking University Health Science Center (Beijing, China), Department of Radiation Medicine

Research focus

DNA damage/radiation-induced DNA damage repair mechanisms and diseases including cancers

Research contents

Specifically, our group utilizes reconstituted biochemical systems, molecular and cellular assays, and animal models, to investigate how various types of DNA damages (radiation-induced DNA damage) are repaired accurately to ensure genome stability and thus prevent the occurrence of diseases such as cancers. Specific ongoing research projects in our lab include:

(1) DNA double-strand break (radiation-induced DNA damage) repair mechanisms, tumorigenesis and tumor cell response to radiation/chemotherapeutic drugs

(2) RNA-DNA hybrid/R-loop resolving and genome instability

(3) DNA interstrand crosslink (ICL) repair and Fanconi anemia (FA) pathway/syndrome

(4) Identification of novel DNA damage repair factors and establishment of their intervention strategies

Grant

(1) 2019: Start-up Research Grant for Newly Introduced Talents

(2) 2020: Grant from the National Natural Science Foundation of China

(3) 2022: Grant from the National Natural Science Foundation of China

(4) 2024: Grant from the National Natural Science Foundation of China

Original research articles (corresponding author)

(1) Zhang T, Yang H, Zhou Z, Bai Y, Wang J, Wang W. Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.  Nature Communications . 2022, 13(1): 5133

(2) Xu Z, Nie C, Liao J, Ma Y, Zhou XA, Li X, Li S, Lin H, Luo Y, Cheng K, Mao Z, Zhang L, Pan Y, Chen Y, Wang W, Wang J. DDX39A resolves replication fork-associated RNA-DNA hybrids to balance fork protection and cleavage for genomic stability maintenance.  Molecular Cell . 2025, 85(3): 490-505

(3) Zhou Z, Yang H, Liang X, Zhou T, Zhang T, Yang Y, Wang J, Wang W. C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair.  Cell Reports . 2023, 42(8): 112907

(4) Zhou Z, Yang H, Liang X, Zhou T, Liu Q, Wang J, Wang W. Reconstitution of the antagonistic effect between C1orf112/FIRRM-FIGNL1 and BRCA2 on RAD51 filament stabilization.  STAR Protocols . 2024, 5(1): 102791

(5) Xu Z, Li X, Li H, Nie C, Liu W, Li S, Liu Z, Wang W, Wang J. Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.  Oncogene . 2020, 39(47): 7051-7062

(6) Yu G, Xiong Y, Xu Z, Zhang L, Zhou XA, Nie C, Li S, Wang W, Li X, Wang J. MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts.  Cancer Gene Therapy . 2024, 31(1): 94-107

Invited reviews (corresponding author)

(1) Zhang T, Zhou Z, Yang H, Wang W. MRE11-RAD50-NBS1-CtIP: one key nuclease ensemble functions in the maintenance of genome stability.  Genome Instability & Disease . 2022, 3: 123-135

(2) Bai Y, Wang W, Wang J. Targeting DNA repair pathways: mechanisms and potential applications in cancer therapy.  Genome Instability & Disease . 2020, 1(6): 318-338

Original research articles (first author):

(1) Wang W, Daley JM, Kwon Y, Krasner DS, Sung P. Plasticity of the Mre11-Rad50-Xrs2-Sae2 nuclease ensemble in the processing of DNA-bound obstacles.  Genes & Development . 2017, 31(23-24): 2331-2336

(2) Bai Y, Wang W, Li S, Zhan J, Li H, Zhao M, Zhou XA, Li S, Li X, Huo Y, Shen Q, Zhou M, Zhang H, Luo J, Sung P, Zhu WG, Xu X, Wang J. C1QBP promotes homologous recombination by stabilizing MRE11 and controlling the assembly and activation of MRE11/RAD50/NBS1 complex.  Molecular Cell . 2019, 75(6): 1299-1314

(3) Wang W, Pan K, Chen Y, Huang C, Zhang X. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.  Nucleic Acids Research . 2012, 40(3): 981-995

(4) Li H, Wang W, Liu X, Paulson KE, Yee AS, Zhang X. Transcriptional factor HBP1 targets p16INK4A, upregulating its expression and consequently is involved in Ras-induced premature senescence.  Oncogene . 2010, 29(36): 5083-5094

(5) Wang W, Daley JM, Kwon Y, Xue X, Krasner DS, Miller AS, Nguyen KA, Williamson EA, Shim EY, Lee SE, Hromas R, Sung P. A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1-Dna2 in long-range DNA end resection.  Journal of Biological Chemistry . 2018, 293(44): 17061-17069

(6) Wang W, Chen Y, Wang S, Hu N, Cao Z, Wang W, Tong T, Zhang X. PIASxalpha ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase.  Journal of Biological Chemistry . 2014, 289(6): 3217-3230