Jiadong Wang, PhD

Boya Distinguished Professor, Peking University, China

Vice-Director of Peking University Health Science Center, and Director of the Department of Radiation Medicine, School of Basic Medical Sciences

Contact Information

Email: wangjd@bjmu.edu.cn;

Website: /jsdw/bssds/Jiadong_Wang.html

Education

•PhD (2003-2008), School of Life Sciences, Fudan University, China

Other positions

•Instructor (2012-2014), Department of Radiation Oncology, M.D. Anderson Cancer Center

•Research Scientist (2009-2012), Department of Radiation Oncology, M.D. Anderson Cancer Center

•Postdoctoral Fellow (2008 – 2009), Department of Experimental Radiation Oncology, Yale University

Research interests

•Mechanisms of Carcinogenesis, BRCA, Therapeutic Resistance in Radiation and Chemotherapy, and Combinatorial Approaches with Immunotherapy

Selected publications

1.Xu Z, Nie C, Liao J, Ma Y, Zhou XA, Li X, Li S, Lin H, Luo Y, Cheng K, Mao Z, Zhang L, Pan Y, Chen Y, Wang W, Wang J*. DDX39A resolves replication fork-associated RNA-DNA hybrids to balance fork protection and cleavage for genomic stability maintenance. Mol Cell. 2025 Feb 6;85(3):490-505. (Cover Story)

2.Luo Y, Li J, Li X, Lin H, Mao Z, Xu Z, Li S, Nie C, Zhou XA, Liao J, Xiong Y, Xu X, Wang J*. The ARK2N-CK2 complex initiates transcription-coupled repair through enhancing the interaction of CSB with lesion-stalled RNAPII. Proc Natl Acad Sci U S A. 2024 Jun 11;121(24):e2404383121.

3.Wang J, Chen Y, Li S, Liu W, Zhou XA, Luo Y, Xu Z, Xiong Y, Cheng K, Ruan M, Yu W, Li X, Wang W, Wang J*. PP2A inhibition causes synthetic lethality in BRCA2-mutated prostate cancer models via spindle assembly checkpoint reactivation. J Clin Invest. 2024 Jan 2;134(1):e172137.

4.Zhou XA, Zhou J, Zhao L, Yu G, Zhan J, Shi C, Yuan R, Wang Y, Chen C, Zhang W, Xu D, Ye Y, Wang W, Shen Z, Wang W, Wang J*. KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28239-28250.

5.Bai Y, Wang W, Li S, Zhan J, Li H, Zhao M, Zhou X, Li S, Li S, Huo Y, Shen Q, Zhou M, Zhang H, Luo J, Sung P, Zhu W, Xu Z, Wang J* C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex. Mol Cell. 2019 Sep 19;75 (6) (Cover Story)