Yuhui Wang, Associate Professor

Contact Information

wangyuhui2009@bjmu.edu.cn, Mobile: 13718686980

Research Direction 

Generation of New Resources for Animal Diseases Models

Study on the Pathophysiological Mechanisms of Multi-organs Damage by Lipid Metabolism Disorders

Personal Profile

Based on the establishment of animal diseases models, the pathological mechanisms and intervention methods was investigated in the field of lipid metabolism and relative diseases, and a series of achievements were obtained. It was the first in the world to establish an genetic engineering technology for golden hamster, which participated in the 12th Five-Year Plan Science and Technology Achievements Exhibition as an original scientific achievement of our country. Then we are continuously supported by a sub-project of the key research and development project of the Ministry of Science and Technology to upgrade and establish a stable genetic modification technology team and application platform for golden hamster. Using personalized disease models, we try to solve scientific problems in multi organ damage from the perspective of glucose and lipid metabolism:

1. Generation of animal disease models, as well as the upgrading of gene modification technology and platform construction, and the establishment of a phenotypic analysis platform based on the finding of characteristics of golden hamster;

2. Using mitochondrial gene editing technology, CRISPR screening technology and omics methods, we study the pathological mechanisms and intervention methods of metabolism-related diseases such as cardiomyopathy, coronary heart disease, fatty liver and acute pancreatitis;

3. Develop new lipid-lowering drugs from the perspective of protein design.

Doctoral supervisor

Currently, I am supervising one regular doctoral student, one eight-year doctoral student, one master's student transferring to a doctoral program, and one master's student.

Scientific research achievements (funds, papers, etc.)

Ongoing projects:1

1. Sub-project: “Establishment of a technical system and platform for resource creation and evaluation” of Key Research and Development Program of the Ministry of Science and Technology: “Research and demonstration of key technologies for enhancing the technological innovation capability of the National Laboratory Animal Resource Bank service” ,December 2021 - December 2026.

2. Computational Design and Drugability Research of Lipoproteins, Beijing Natural Science Foundation, Key Research Topic, October 2023 - December 2027.

Recent representative publications

1. Miao GL#, Zhang WX#, Xu YT#, Liu YR#, Lai PP, Guo JB, Chen GL, Chen JX, Zhou ZH, Li YW, Zhang C, Ding Y, Zhang LX, Han YF, Chen JX, Wu JD, Zhao YQ, Mei S, Zhao Y, Ma YW, Zhang L, Huang W, Zhao DY*, Dong ED*, Wang YH(*), Xian XD*. Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease. Mil Med Res. 2025 Mar 4;12(1):11. doi: 10.1186/s40779-025-00594-3. IF="22.9

2. Liao J#, Wang Y(#), Wang Y, Zhang J, Wu F, Liu G, Huang W*, Zhang Y*. Human ApoC3 overexpression aggravates hyperlipidemia but mitigates diet-induced coronary atherosclerotic disease in SR-BI and LDL receptor double knockout mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Apr;1869(3):159449. IF="3.3

3. Lin X(#), Zhang W(#), Yang C, Ma P, He K, Chen G, Tao Y, Yan H, Yang Z, Zhang L, Fan J, Cui Q, Huang W, Liu G, Xian X(*), Wang Y(*). Depleting LCAT Aggravates Atherosclerosis in LDLR-deficient Hamster with Reduced LDL-Cholesterol Level. J Adv Res. 2023 Nov 2:S2090-1232(23)00320-X. doi: 10.1016/j.jare.2023.10.016. Online ahead of print. IF="13.0

4. Lin X, Ma P, Yang C, Wang J, He K, Chen G, Huang W, Fan J, Xian X, Wang Y(*), Liu G. Dietary-Induced Elevations of Triglyceride-Rich Lipoproteins Promote Atherosclerosis in the Low-Density Lipoprotein Receptor Knockout Syrian Golden Hamster. Front Cardiovasc Med. 2021 Nov 2;8:738060. doi: 10.3389/fcvm.2021.738060. eCollection 2021. IF="2.9

5. Zhang Y(#), He W(#), He C, Wan J, Lin X, Zheng X, Li L, Li X, Yang X, Yu B, Xian X, Zhu Y, Wang Y(*), Liu G, Lu N(*). Large triglyceride-rich lipoproteins in hypertriglyceridemia are associated with the severity of acute pancreatitis in experimental mice. Cell Death Dis. 2019 Sep 30;10(10):728.   IF="9.6